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J08

A new aproach to biodegradation

○Yoshiyuki Noguchi（National Institute of Technology and Evaluation, Chemical management center），Yuki Sakuratani（National Institute of Technology and Evaluation, Chemical management center），Kenji Kasai（National Institute of Technology and Evaluation, Chemical management center），Jun Yamada（National Institute of Technology and Evaluation, Chemical management center），Tsutomu Nishihara（Osaka University）

The actual measurements of safety data for existing chemicals have not proceed for many years in Japan as well as in OECD countries, because it takes huge expenses, time and labor.In order to solve those problems, the authorities for the management of chemical substances in each country have been making their efforts to utilize the prediction by (Quantitative) Structure Activity Relationships [(Q)SAR] in place of actual measurement. As for the biodegradation data, Japan have been accumulating reliable data for many years, which is utilized globally for the research and development of (Q)SAR systems.NITE focused its attention to separate biotic reaction and abiotic reaction occurring in the biodegradation measurement system. Those reactions are based on quite different mechanism, it would be useful to separate abiotic reaction from biotic reaction to improve the predictivity of biotic reaction.NITE started the program of developing the prediction system for abiotic hydrolysis of chemicals based on the molecular orbital method.